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Epinephrine - Because of the opportunity for promethazine to reverse epinephrine’s vasopressor effect, epinephrine really should not be used to take care of hypotension related to promethazine overdose.

The subsequent laboratory exams might be impacted in people who're obtaining therapy with promethazine hydrochloride.

Pregnancy Assessments Diagnostic pregnancy exams determined by immunological reactions involving HCG and anti-HCG may bring about Bogus-destructive or false-good interpretations.

The next severe adverse reactions are explained, or described in bigger detail, in other sections:

Promethazine and codeine may possibly induce marked drowsiness or may well impair the mental and/or physical talents needed with the effectiveness of potentially harmful tasks, like driving a auto or functioning equipment.

Having said that, this outcome is not consistent and may be offset by an elevated amount of cervical dilation, which has a tendency to shorten labor. Keep an eye on neonates exposed to opioids in the course of labor for signs of excessive sedation and respiratory melancholy.

Unresponsive Cough The dosage of Promethazine HCl and Codeine Phosphate Oral Option should not be elevated if cough fails to respond; an unresponsive cough need to be reevaluated in 5 days get more info or quicker for achievable fundamental pathology, which include foreign system or reduced respiratory tract condition [see Dosage and Administration (two.3)].

Distinct reports to test the action in the drug on parturition, lactation, and enhancement of your animal neonate weren't carried out, but a basic preliminary analyze in rats indicated no impact on these parameters.

g., amiodarone, quinidine) may perhaps cause a rise in codeine plasma concentrations as well as a minimize in active metabolite morphine plasma concentration which could end in an analgesic efficacy reduction or indicators of opioid withdrawal.

An increased danger of certain malformations with codeine exposure including respiratory malformations, spina bifida and congenital heart defects had been noted in some research.

Don't use a domestic teaspoon to measure your drugs. It's possible you'll unintentionally just take an excessive amount. You could request your pharmacist for that measuring device you should use and the way to measure the right dose.

Interest needs to be given to your reestablishment of sufficient respiratory Trade through provision of a patent airway and establishment of assisted or managed ventilation. Diazepam could be employed to regulate convulsions. Acidosis and electrolyte losses really should be corrected. Notice that any depressant effects of Promethazine HCl aren't reversed by naloxone. Avoid analeptics which can cause convulsions.

Lactation No less than just one Dying was described in a very nursing infant who was exposed to superior amounts of morphine in breast milk because the mom was an ultra-fast metabolizer of codeine.

Sedation in both equally youngsters and Older people, and also aid of apprehension and manufacture of light-weight rest from which the affected individual might be easily aroused.